Saturday, April 29, 2017

Francisco Goya's Mystery Illness

Francisco Goya
The famous Spanish painter Francisco Goya suffered a mysterious illness and lost his hearing at the age of 46, and now experts may have figured out why.
Goya is considered the most important Spanish painter of the late 18th and early 19th centuries. But in the middle of his career, in 1793, he developed a severe illness that left him bedridden for months. He experienced headaches, dizziness, hallucinations, vision problems and ringing in his ears. Most of these symptoms eventually went away, but the illness left him deaf. He lived to be 82 years old.

At the time he got sick, Goya's illness went undiagnosed, and since then, some experts have speculated that he had bacterial meningitis or syphilis, or had developed lead poisoning from working with paint.

But in a new analysis, Dr. Ronna Hertzano, a surgeon and hearing expert at the University of Maryland School of Medicine, said that Goya may have suffered from an autoimmune disease called Susac's syndrome. In this rare condition, a person's immune system attacks small blood vessels in the brain, retina and inner ear, according to the Cleveland Clinic. Symptoms can include severe headaches, difficulties thinking, psychiatric problems and loss of vision, balance and hearing.

Figuring out a possible diagnosis for Goya's case was a challenge, because "for this particular (case), we do not have written records from his physicians," Hertzano, said. Nevertheless, Goya "had a certain constellation of symptoms" that gave the researchers clues to a possible diagnosis.
Susac's syndrome would "explain all of his symptoms" and can leave patients with lasting hearing loss, Hertzano added.
Although syphilis, bacterial meningitis and lead poisoning could all also explain Goya's symptoms, the people who had those conditions in the 18th century usually did not recover the way that Goya did, Hertzano said. Patients with these diseases would be expected to have persistent, progressive disorders, or additional complications, rather than to get better as the famous painter did.Still, Hertzano noted that there is no way to make a definitive diagnosis in this case. "The best we can do is speculate," she said.
If Goya had been treated today, doctors would likely have identified the cause of his disease promptly, but "it's still possible that he would have ultimately had hearing loss despite modern medicine," Hertzano said. But today, the painter could receive cochlear implants, which can restore hearing, she added.
Hertzano will present her research on Goya's case on at the Historical Clinicopathological Conference at its annual meeting devoted to the diagnosis of historical figures.
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Paintings by Francisco Goya




















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